Rocuronium bromide is a commonly used pharmaceutical intermediate, the chemical name is tris (2-bromopropyl) trimethoxy ammonium salt. It is a colorless or slightly yellow crystalline solid with a strong pungent odor. It has good solubility, soluble in water, alcohol and ketone solvents.
Rocuronium bromide has a wide range of uses. It is commonly used in the preparation of ion exchange resins, catalysts and catalysts for organic synthesis reactions. In the field of medicine, rocuronium is also an important intermediate for the preparation of certain drugs, such as the antihypertensive drugs budesonide and furosemide.
The method for preparing rocuronium bromide is usually obtained by reacting tris (2-bromopropyl) ammonium oxide with a base. The reaction is essentially divided into two steps: first, tris (2-bromopropyl) ammonium oxide is reacted with a base to form tris (2-bromopropyl) iminium oxide; and then, tris (2-bromopropyl) iminium oxide is reacted with a base to form rocuronium bromide.
In the process of using rocuronium bromide, it is necessary to pay attention to its safety information. Rocuronium is irritating, please avoid contact with skin and eyes. Wear goggles, gloves and protective clothing during operation. In addition, it should be away from fire and heat sources, avoid contact with oxidants and strong acids to prevent dangerous reactions. Please store and handle rocuronium properly to avoid environmental pollution.